TSE Systems

IntelliCage for mice

IntelliCage allows normal social behavior of mice and respects animal welfare. Your mice will act and react more naturally in an undisturbed environment while living in their normal social circle – increasing the quality and comparability of your data while minimizing your effort!

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Key features

  • fully automated screening for behavioral and cognitive functions of mice living in social groups in a home cage equipped with 4 programmable operant corners
  • transponder technology permits assessment of individual performance
  • high level of standardization achieved by minimizing human disturbance and performing automated monitoring
  • allows uninterrupted short- or long-term monitoring
  • permits investigators to focus on mechanistic analysis of detected effects
  • animal friendly: group living reduces "stereotypes", more natural behavior can be observed
  • user friendly software modules: no detailed behavioral know-how necessary
  • IntelliCage for Rats using the same proven technology
  • AnimalGate for individually controlled access to new arenas
  • SocialBox for the monitoring of social interactions in mice
  • AudioBox for acoustic conditioning in connection with a home cage

IntelliCage functionality


IntelliCage Webinar Clip: "How to Investigate Behavior and Cognitive Abilities of Individual Rodents in a Social Group"



IntelliCage as a tool for measuring mouse behavior – 20 years perspective

Anna Kiryk, Artur Janusz, Bartosz Zglinicki, Emir Turkes, Ewelina Knapska, Witold Konopka, Hans-Peter Lipp,Leszek Kaczmarek
Behavioural Brain Research, Volume 388, 18 June 2020, 112620


Early deprivation induces competitive subordinance in C57BL/6 male mice.

Benner S, Endo T, Endo N, Kakeyama M, Tohyama C.
Physiol Behav 2014; 137C:42-52

Frequency Tuning in the Behaving Mouse: Different Bandwidths for Discrimination and Generalization.

de Hoz L, Nelken I. 
PLoS One 2014; 9(3):e91676

Early life stress in fathers improves behavioural flexibility in their offspring.

Gapp K, Soldado-Magraner S, Alvarez-Sánchez M, Bohacek J, Vernaz G, Shu H, Franklin TB, Wolfer D, Mansuy IM. 
Nat Commun 2014; 5:5466

Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment.

Kulesskaya N, Karpova NN, Ma L, Tian L, Voikar V.
Front Behav Neurosci 2014, 8:257

The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6−/− mouse model.

Patrikainen M, Pan P, Kulesskaya N, Voikar V, Parkkila S. 
J Biomed Sci 2014; 21:82

A novel automated behavioral test battery assessing cognitive rigidity in two genetic mouse models of autism.

Puscian A, Lęski S, Górkiewicz T, Meyza K, Lipp HP, Knapska E.
Front Behav Neurosci 2014; 8:140 

A Model of Alcohol Drinking under an Intermittent Access Schedule Using Group-Housed Mice.

Smutek M, Turbasa M, Sikora M, Piechota M, Zajdel J, Przewlocki R, Parkitna JR. 
PLoS One 2014; 9(5):e96787

The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis.

Too LK, Ball HJ, McGregor IS, Hunt NH.
Brain Behav Immun 2014; 40:262-68

The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis.

Too LK, McQuillan JA, Ball HJ, Kanai M, Nakamura T, Funakoshi H, McGregor IS, Hunt NH.
Behav Brain Res 2014; 270:179-95

Automated phenotyping and advanced data mining exemplified in rats transgenic for Huntington's disease.

Urbach YK, Raber KA, Canneva F, Plank AC, Andreasson T, Ponten H, Kullingsjö J, Nguyen HP, Riess O, von Hörsten S.  
J Neurosci Methods 2014; 234:38-53


Spontaneous behavior in the social homecage discriminates strains,lesions and mutations in mice.

Vannoni E, Voikar V, Colacicco G, Sánchez MA, Lipp HP, Wolfer DP.  
J Neurosci Methods 2014; 234:26-37



Learning and memory with neuropathic pain: impact of old age and progranulin deficiency.

Albuquerque B, Häussler A, Vannoni E, Wolfer DP, Tegeder I.
Front Behav Neurosci 2013; 7:174

Antidepressant treatment outcome depends on the quality of the living environment: a pre-clinical investigation in mice.

Branchi I, Santarelli S, Capoccia S, Poggini S, D’Andrea I, Cirulli F, Alleva E.
PlosOne 2013; 8(4): e62226

Loss of hippocampal neurogenesis, increased novelty-induced activity, decreased home cage activity, and impaired reversal learning one year after irradiation of the young mouse brain.

Kalm M, Karlsson N, Nilsson MK, Blomgren K.
Exp Neurol 2013; 247:402-9

Measuring basal and complex behaviors of rats in automated social home cage systems using IntelliCage for rat technology.

Knapska E, Lioudyno V, Kiryk A, Mikosz M, Górkiewicz T, Michaluk P, Gawlak M, Chaturvedi M, Mochol G, Balcerzyk M, Wojcik DK, Wilczynski GM, Kaczmarek L.
J Neurosci 2013; 33(36): 14591-600

Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice.

Kobayashi Y, Sano Y, Vannoni E, Goto H, Suzuki H, Oba A, Kawasaki H, Kanba S, Lipp HP, Murphy NP, Wolfer DP, Itohara S.
Front Behav Neurosci 2013; 07: 17

CD73 is a major regulator of adenosinergic signalling in mouse brain.

Kulesskaya N, Võikar V, Peltola M, Yegutkin GG, Salmi M, Jalkanen S, Rauvala H.
PLoS One 2013; 8(6):e66896

Social behavior is perturbed in mice after exposure to bisphenol A: a novel assessment employing an IntelliCage.

Ogi H, Itoh K, Fushiki S.
Brain Behav 2013; 3(3):223-8

Transplantation of enteric neural stem/progenitor cells into the irradiated young mouse hippocampus.

Osman AM, Zhou K, Zhu C, Blomgren K.
Cell Transplant 2013 [Epub ahead of print]

Novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice are controlled by metabotropic glutamate receptor 5 on controlled by metabotropic glutamate receptor 5 on neurons expressing dopamine D1 receptors.

Parkitna JR, Sikora M, Gołda S, Gołembiowska K, Bystrowska B, Engblom D, Bilbao A, Przewlocki R.
Biological Psychiatry 2013; 73(3): 263-70

Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent.

Ryan D, Koss D, Porcu E, Woodcock H, Robinson L, Platt B, Riedel G.
Cell Mol Life Sci 2013; 70(14):2603-19 

A novel automated test battery reveals enduring behavioural alterations and cognitive impairments in survivors of murine pneumococcal meningitis.

Too LK, Ball HJ, McGregor IS, Hunt NH.
Brain Behav Immun 2013; Epub

LRRTM1-deficient mice show a rare phenotype of avoiding small enclosures--a tentative mouse model for claustrophobia-like behavior.

Voikar V, Kulesskaya N, Laakso T, Lauren J, Strittmatter SM, Airaksinen MS.
Behav Brain Res.2013; 238:69-78



Effects of spatial and cognitive enrichment on activity pattern and learning performance in three strains of mice in the IntelliMaze.

Codita A, Mohammed AH, Willuweit A, Reichelt A, Alleva E, Branchi I, Cirulli F, Colacicco G, Voikar V, Wolfer DP, Buschmann FJ, Lipp HP, Vannoni E, Krackow S.
Behav Genet 2012; 42(3):449-60

Executive function deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via lactation.

Endo T, Kakeyama M, Uemura Y, Haijima A, Okuno H, Bito H, Tohyama C.
PLoS One 2012; 7(12):e50741

Lithium reduced neural progenitor apoptosis in the hippocampus and ameliorated functional deficits after irradiation to the immature mouse brain.

Huo K, Sun Y, Li H, Du X, Wang X, Karlsson N, Zhu C, Blomgren K.
Mol Cell Neurosci 2012; 51(1-2):32-42

Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning ability

Jedynak P, Jaholkowski P, Wozniak G, Sandi C, Kaczmarek L, Filipkowski RK
BBR 2012; 227:159-166
IntelliCage Mouse

Characterization of an alcohol addiction-prone phenotype in mice.

Radwanska K, Kaczmarek L.
Addict Biol 2012; 17(3):601-12

Dysregulation of Rho GTPases in the {alpha}Pix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.

Ramakers GJ, Wolfer D, Rosenberger G, Kuchenbecker K, Kreienkamp HJ, Prange-Kiel J, Rune G, Richter K, Langnaese K, Masneuf S, Bösl MR, Fischer KD, Krugers HJ, Lipp HP, van Galen E, Kutsche K.
Hum Mol Genet 2011; 21(2): 268-86

Sex-dependent differences in behavior and hippocampal neurogenesis after irradiation to the young mouse brain.

Roughton K, Kalm M, Blomgren K.
Eur J Neurosci 2012; 36(6): 2763-72


Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage

Endo T, Maekawa F, Võikar V, Haijima A, Uemura Y, Zhan Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama
Behav Brain Res 2011; 221(1):172-81
IntelliCage Mouse

Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice

Ermakova O, Piszcek L, Luciani L, Cavalli FMG, Ferreira T, Farley D, Rizzo S, Paolicelli RC, Al-Banchaabouchi M, Nerlov C, Moriggl R, Luscombe NM, Gross C
EMBO Mol Med 2011; 3:50-66
VideoMot, IntelliCage Mouse

Comprehensive behavioral phenotyping of Ts65Dn mouse model of down syndrome: Activation of beta1-adrenergic receptor vy xamoterol as a potential cognitive enhancer

Faizi M, Bader PL, Tun C, Encarnacion A, Kleschevnikov A, Belichenko P, Saw N, Priestley M, Tsien RW, Mobley WC, Shamloo M
Neurobiol Dis 2011; :1-17
IntelliCage Mouse

Learning and activity after irradiation of the young mouse brain analyzed in adulthood using unbiased monitoring in a home cage environment

Karlsson N, Kalm M, Nilsson MK, Mallard C, Björk-Eriksson T, Blomgren K
Radiat Res 2011; 175(3):336-346
IntelliCage Mouse

Cognitive abilities of Alzheimer´s disease transgenic micce are modulated by social context and circadian rhythm

Kiryk A, Mochol G, Filipkowski RK, Wawrzyniak M, Lioudyno V, Knapska E, Gorkiewicz T, Balcerzsk M, Lemski S, Van Leuven F, Lipp HP, Wójcik DK, Kaczmarek L
Curr Alzheimer Res 2011; 8(8):883-892
IntelliCage Mouse

Sex-specific cognitive deficits and regional brain volume loss in mice exposed to chronic, sublethal hypoxia

Lan WCJ, Priestley M, Mayoral SR, Tian L, Shamloo M, Penn AA
Pediatr Res 2011; 70(1):15-20
IntelliCage Mouse

Characterization of an alcohol addiction-prone phenotype in mice

Radwanska K, Kaczmarek L
Addict Biol 2011; :doi: 10.1111/j.1369-1600.2011.00394.x
IntelliCage Mouse

Dysregulation of Rho GTPases in the {alpha}Pix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.

Ramakers GJ, Wolfer D, Rosenberger G, Kuchenbecker K, Kreienkamp HJ, Prange-Kiel J, Rune G, Richter K, Langnaese K, Masneuf S, Bösl MR, Fischer KD, Krugers HJ, Lipp HP, van Galen E, Kutsche K.
Hum Mol Genet 2011; doi;10.1093:
IntelliCage Mouse

Effects of yokukansan and donepezil on learning disturbance and aggressiveness induced by intracerebroventricular injection of amyloid beta protein in mice

Sekiguchi K, Imamura S, Yamaguchi T, Tabuchi M, Kanno H, Terawaki K, Kase Y, Ikarashi Y
Phytother Res 2011; 25:501-7
IntelliCage Mouse

Mice Lacking Ras-GRF1 Show Contextual Fear Conditioning but not Spatial Memory Impairments: Convergent Evidence from Two Independently Generated Mouse Mutant Lines

d’Isa R, Clapcote SJ, Voikar V, Wolfer DP, Giese KP, Brambilla R, Fasano S
Front Behav Neurosci 2011; 5:78:Epub Dec 6
IntelliCage Mouse


Decreased cytogenesis in the granule cell layer of the hippocampus and impaired place learning after irradiation of the young mouse brain evaluated using the IntelliCage platform

Barlind A, Karlsson N, Björk-Eriksson T, Isgaard J, Blomgren K
Exp Brain Res 2010; 201(4):781-787
IntelliCage Mouse

Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: a longitudinal study

Codita A, Gumucio A, Lannfelt L, Gellerfors P, Winblad B, Mohammed AH, Nilsson LNG
Behav Brain Res 2010; 215:83-94
IntelliCage Mouse

MicroRNA loss enhances learning and memory in mice

Konopka W, Kiryk A, Novak M, Herwerth M, Parkitna JR, Wawrzyniak M, Kowarsch A, Michaluk P, Dzwonek J, Arnsperger T, Wilczynski G, Merkenschlager M, Theis FJ, Köhr G, Kaczmarek L, Schütz G
J Neurosci 2010; 30(44):14835-42
IntelliCage Mouse, RotaRod

Consistent behavioral phenotype differences between inbred mouse strains in the IntelliCage

Krackow S, Vannoni E, Codita A, Mohammed AH, Cirulli F, Branchi I, Alleva E, Reichelt A, Willuweit A, Voikar V, Colacicco G, Wolfer DP, Buschmann JU, Safi K, Lipp HP
Genes Brain Behav 2010; 9(7):722-731
IntelliCage Mouse

Guidlines for preclinical animal research in ALS/MND: A consensus meeting

Ludolph AC, Bendotti C, Blaugrund E, Chio A, Greensmith L, Loeffler JP, Mead R, Niessen HG, Petri S, Pradat PF, Robberecht W, Ruegg M, Schwalenstöcker B, Stiller D, Van Den Berg L, Vieira F, Von Horsten S
Amyotroph Lateral Scler 2010; 11:38-45
IntelliCage Mouse, PhenoMaster

Neurobehavioral tests in rat models of degenerative brain diseases

Urbach YK, Bode FJ, Jguyen HP, Riess O, von Hörsten S
Methods Mol Biol 2010; 597:333-52
IntelliCage Mouse, PhenoMaster

Conditioned response suppression in the IntelliCage: assessment of mouse strain differences and effects of hippocampal and striatal lesions on acquisition and retention of memory

Voikar V, Colacicco G, Gruber O, Vannoni E, Lipp HP, Wolfer DP
Behav Brain Res 2010; 213:304-312
IntelliCage Mouse


Shaping brain development: mouse communal nesting blunts adult neuroendocrine and behavioral response to social stress and modifies chronic antidepressant treatment outcome

Branchi I, D’Andrea I, Cirulli F, Lipp HP, Alleva E
Psychoneuroendocrinology 2009; 35(5):743-751
IntelliCage Mouse

New hippocampal neurons are not obligatory for memory formation; cyclin D2 knockout mice with no adult brain neurogenesis show learning

Jaholkowski P, Kiryk A, Jedynak P, Ben Abdallah NM, Knapska E, Kowalczyk A, Piechal A, Blecharz-Klin K, Figiel I, Lioudyno V, Widy-Tyszkiewicz E, Wilczynski GM, Lipp HP, Kaczmarek L, Filipkowski RK
Learn Mem 2009; 16(7):439-451
IntelliCage Mouse

A comparison of learning and memory characteristics of young and middle-aged wild-type mice in the IntelliCage

Mechan AO, Wyss A, Rieger H, Mohajeri MH
J Neurosci Methods 2009; 180(1):43-51
IntelliCage Mouse

Detection of early behavioral markers of Huntington’s disease in R6/2 mice employing an automated social home cage

Rudenko O, Tkach V, Berezin V, Bock E
Behav Brain Res 2009; 203(2):188-199
IntelliCage Mouse

Germline expression of H-Ras(G12V) causes neurological deficits associated to Costello syndrome

Viosca J, Schuhmacher AJ, Guerra C, Barco A
Genes Brain Behav 2009; 8(1):60-71
IntelliCage Mouse

Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents

Zhu C, Gao J, Karlsson N, Li Q, Zhang Y, Huang Z, Li H, Kuhn HG, Blomgren K
J Cereb Blood Flow Metab 2009; 30(5):1017-1030
IntelliCage Mouse


A robust automated system elucidates mouse home cage behavioral structure

Goulding, EH, Schenk AK, Juneja P, MacKay AW, Wade JM, Tecott LH
PNAS 2008; 105 (52):20575-20582
IntelliCage Mouse

Behavioral characterization of GLT1 (+/-) mice as a model of mild glutamatergic hyperfunction.

Kiryk A, Aida T, Tanaka K, Banerjee P, Wilczynski GM, Meyza K, Knapska E, Filipkowski RK, Kaczmarek L, Danysz W
Neurotox Res 2008; 13(1):19-30
IntelliCage Mouse


Developmental exposure to methylmercury alters learning and induces depression-like behavior in male mice

Onishchenko N, Tamm C, Vahter M, Hökfelt T, Johnson JA, Johnson DA, Ceccatelli S
Toxicol Sci 2007; 97(2):428-437
IntelliCage Mouse


Differential involvement of the central amygdala in appetitive versus aversive learning

Knapska E, Walasek G, Nikolaev E, Neuhäusser-Wespy F, Lipp HP, Kaczmarek L, Werka T
Learn Mem 2006; 13(2):192-200
IntelliCage Mouse

Mouse anxiety models and an example of an experimental setup using unconditioned avoidance in an automated system – IntelliCage

Safi K, Neuhäusser-Wespy F, Welzl H, Lipp HP
Cognition, Brain, Behavior 2006; 10:475-488
IntelliCage Mouse

Advanced behavioral screening: automated home cage ethology

Spruijt BM, DeVisser L
Drug Discov Today Technol 2006; 3(2):231-237
IntelliCage Mouse, PhenoMaster / LabMaster


A comparison of wild-caught wood mice and bank voles in the Intellicage: assessing exploration, daily activity patterns and place learning paradigms.

Galsworthy MJ, Amrein I, Kuptsov PA, Poletaeva II, Zinn P, Rau A, Vyssotski A, Lipp HP
Behav Brain Res 2005; 157:211-217
IntelliCage Mouse

High-throughput and automated behavioral screening of normal and genetically modified mice

Lipp HP
usiness Briefing: Future Drug Discovery 2005 2005; :1-5
IntelliCage Mouse


Can a mouse be standardized?

Bohannon J
Science 2002; 298:2320-2321
IntelliCage Mouse